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DTSTART;TZID=Europe/Copenhagen:20270308T173000
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DTSTAMP:20260909T090134Z
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SUMMARY:Genomic Mechanisms of Disease 2027
DESCRIPTION:Recent years have seen remarkable progress in mapping the genetic basis of human disease and complex traits. Yet translating genetic associations into an understanding of disease mechanisms—and ultimately into new therapeutic opportunities—remains a major challenge. At the same time\, advances in high-throughput functional genomics\, stem-cell models\, spatial and cellular profiling\, and artificial intelligence are creating a new opportunity: to move from cataloging biological complexity toward building predictive models of human biology and disease. \nRealizing this opportunity will require a new scale of experimentation and integration. Population-scale human genetics can identify the variants\, genes\, and pathways associated with disease; systematic perturbation and multimodal cellular measurements can reveal their functional consequences; and increasingly powerful AI models can learn from these data to predict how genetic and environmental perturbations reshape cellular states. Together\, these approaches offer the possibility of connecting human genetic variation to molecular and cellular mechanisms at unprecedented scale—and of using those insights to generate and prioritize therapeutic hypotheses. \nThe Novo Nordisk Foundation Science Cluster Conference will bring together global thought leaders across seven interconnected themes: statistical & population genomics\, gene regulation\, functional genomics & technology development\, AI/ML & computational modeling\, disease mechanisms & models\, therapeutics & translation\, and somatic mosaicism & disease. \nBy connecting discoveries across these disciplines—from inherited and somatic genetic variation and gene regulation to large-scale perturbational biology\, predictive AI models\, and therapeutic development—we aim to explore how the field can build and validate increasingly quantitative and predictive models of human disease across the lifespan and use these models to accelerate translational discoveries and the development of therapeutics. Together\, these advances will transform our ability to interpret genetic variation\, uncover disease mechanisms\, identify therapeutic targets\, and ultimately enable preventive strategies\, genomic medicine\, and rationally designed treatments.
URL:https://ddsa.dk/event/genomic-mechanisms-of-disease-2027/
LOCATION:Favrholm Campus\, Roskildevej 58\, Hillerød\, 3400\, Denmark
CATEGORIES:Other Events
ATTACH;FMTTYPE=image/jpeg:https://ddsa.dk/wp-content/uploads/2026/09/Genomic-Mechanism-of-Disease-2027-Poster.jpg
ORGANIZER;CN="Novo Nordisk Foundation Science Cluster":MAILTO:JJA@novo.dk
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