The etiology of complex diseases concerns not only the DNA sequence variation of a gene, but most importantly also the functional regulation of the gene triggered by specific environmental stimuli. Epigenetics is a newly emerging field of genetic study that focuses on the dynamic aspects of gene activity regulation under given environmental conditions, a very hot topic in many areas of medical research. This course focuses on the design and analysis of epigenomic studies using high-throughput microarray technology with issues concerning study design, biosample collection, data preprocessing, normalization, quality control, statistical and bioinformatic analyses, biological pathway-based analysis and functional interpretation. Students are introduced to the cutting-edge development in epigenetic analysis of human diseases and learn about epigenomic data structure, state-of-the-art data analysis with multiple free software packages.
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